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Beyond IVF, Reproduction Without an Egg and Sperm

The possibility of making a new person from skin or blood cells – without the need for sex goes well beyond in vitro fertilization, which combines egg and sperm in a laboratory, because it doesn't require natural eggs or sperm. In vitro gametogenesis (IVG) is an experimental technique that allows scientists to grow embryos in a lab by reprogramming adult cells to become sperm and egg cells

This technology would allow same-sex couples to have genetically related children, and it could help to conserve endangered species. A Japanese researcher Katsuhiko Hayashi demonstrated recently that he can transform skin cells from adult male mice into healthy eggs. A tiny fraction of the mouse eggs he made were viable, but the mice grown from these egg cells were healthy and able to have pups and grand pups of their own. He envisions using this approach to treat infertility in people who have extra sex chromosomes, such as XXY or XYY, as compared with the typical XX for females and XY for males. It also could allow single-sex couples to have a child who is biologically related to both parents.

The ethical acumen that will have to be debated are questions including the safety of the technique and how many embryos would have to be sacrificed in the process’

Additionally, some worry that IVG could lead to the creation of "designer babies" and exacerbate existing inequalities’ One of the potential risks of in vitro gametogenesis (IVG) is the significant health risks to the resulting child IVG carries the risk of introducing harmful genetic mutations Therefore it will be important to consider these potential risks and ethical concerns before the advent of IVG technology. In conclusion the ramifications of such technology is such that IVG doesn't manipulate with genetics, it just uses the programs already in place in a cell to give it a different function – turning a skin cell into a sperm cell, for instance. As this is accomplished, this can be done in an unlimited way, whereby people could choose among dozens, hundreds or thousands of embryos, compared with IVF in which just a handful of embryos are created.

Ref: https://www.nature.com/articles/s41586-023-05834-x

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